Novo Nordisk's denecimig (Mim8) demonstrated positive results in long term safety and efficacy in phase 3 hemophilia A FRONTIER extension study at ISTH 2026

Novo Nordisk today unveiled new data from the phase 3 FRONTIER4 extension study evaluating the long-term safety and efficacy of investigational denecimig (Mim8) subcutaneous prophylaxis in children, adolescents, and adults with hemophilia A, with or without inhibitors, across a range of dosing frequencies including once-monthly, once-every-two-weeks, and once-weekly administration.

These results and other data across Novo Nordisk's hemophilia portfolio were presented at the International Society on Thrombosis and Haemostasis (ISTH) Congress in Paris.

"The positive safety and efficacy findings from FRONTIER4 reinforce denecimig's potential as a preventive treatment option for children, adolescents, and adults with hemophilia A, regardless of their inhibitor status or the dosing frequency used," said Dr. Martin Holst Lange, chief scientific officer and executive vice president, Research & Development at Novo Nordisk.

Interim analyses from the open-label, phase 3 FRONTIER4 long-term safety and efficacy study included 426 people with hemophilia A aged 1 year and older on denecimig prophylaxis (365 adults and adolescents with a median observation period of 0.50 years; 61 children ...