Amylyx Pharmaceuticals, Inc. (AMLX) Presents at Morgan Stanley 24th Annual Global Healthcare Conference Transcript

SA Transcripts 162.21K Followers Follow Amylyx Pharmaceuticals, Inc. ( AMLX ) Morgan Stanley 24th Annual Global Healthcare Conference September 15, 2026 12:20 PM EDT Company Participants Joshua Cohen - Co-Founder, Co-CEO & Director Justin Klee - Co-CEO & Director Conference Call Participants Cailin Mcgurk Presentation Cailin Mcgurk Perfect. So welcome, everybody. I'm Cailin McGurk. I'm a member of the investment banking team at Morgan Stanley. It is my pleasure, my absolute pleasure, to welcome Josh Cohen and Justin Klee, Co-founders of Amylyx, to the stage today. Just a very brief disclaimer before we get started. You've been to many of these before. Please visit the Morgan Stanley Research Disclosure website, www.morganstanley.com/researchdisclosures for important information about this and other presentations. So without further ado, it's fantastic to have you at our conference. Question-and-Answer Session Cailin Mcgurk It's been a highly eventful and highly successful summer at Amylyx with the amazing data you had on Avexitide and PBH over August. Let's start there because obviously it's the burning question. Let's talk a little bit about the data, you know, firstly in terms of the headline results, what you saw, what you were expecting, and then obviously a lot of follow-up questions on this topic. Joshua Cohen Co-Founder, Co-CEO & Director Sure, yes. So first I'd say, we had high expectations given all of the prior trials of the Avexitide, but I'd say this exceeded our expectations. The data, just to, kind of, highlight, on our pre-specified primary outcome, which was the rate of level 2 and level 3 hypoglycemia in people living with PBH, these are events that are extremely debilitating. Any one of these events is considered a medical emergency. We saw a 55% reduction with the active versus placebo with a p-value of 0.000003. We hit all of our secondary outcomes, also with high statistical significance, similar effect sizes as well.